Pilosa Flower, 1883
Acratocnus Anthony, 1916
Ahytherium
Choloepus Illiger, 1811
Diodomus Ameghino, 1885
Eleutherodon Kermack, Kermack, Lees & Mills, 1998
Eucholoeops Ameghino, 1887
Habanocnus Mayo, 1978
Imagocnus MacPhee & Iturralde-Vincent, 1994
Megalocnus Leidy, 1868
Megalonychops Kraglievich, 1927
Megalonychotherium Scott, 1904
Megalonyx Jefferson, 1799
Meizonyx Webb & Perrigo, 1985
Menilaus Ameghino, 1891
Mesocnus Matthew, 1931
Miocnus Matthew, 1931
Morotherium Marsh, 1874
Neocnus Arredondo, 1961
Neomesocnus
Ortotherium Ameghino, 1885
Paranabradys Scillato-Yane, 1981
Parocnus Miller, 1929
Paulocnus Hooijer, 1962
Pliometanastes Hirschfeld & Webb, 1968
Pliomorphus Ameghino, 1885
Proschismotherium Ameghino, 1902
Protomegalonyx Kraglievich, 1922
Pseudortotherium
Sinclairia Ameghino, 1912
Synocnus
Torcellia Kraglievich, 1931
Valgipes Gervais, 1873